Epigenetic changes are chemical changes on DNA that can cause genes to become silenced or activated for many generations. These changes can be inherited from parent to child, but they are also reversible. It is well documented that health disparities significantly impact African Americans, however the mechanisms underlying these health outcomes are not fully understood. In this presentation, I will discuss the latest research that suggests epigenetics provide a link between environmental factors and increased mortality and morbidity among African Americans. Understanding the mechanisms that underlie racial health disparities is an important step in reducing this health gap.